Sclerostin and bone metabolism markers in hyperthyroidism before treatment and interrelations between them

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Sclerostin and bone metabolism markers in hyperthyroidism before treatment and interrelations between them.

Sclerostin, which is a glycoprotein produced by osteocytes, reduces the formation of bones by inhibiting the Wnt signal pathway. Thyroid hormones are related with Wnt signal pathway and it has been reported that increased thyroid hormones in hyperthyroidism fasten epiphysis maturation in childhood, and increase the risk of bone fractures by stimulating the bone loss in adults. The aim of this s...

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Bone Mineral Density and Bone Metabolic Markers in Children with Hyperthyroidism Before and During Treatment

Increased bone turnover and loss of bone mass in adult patients with hyperthyroidism is well documented, but bone manifestations in children with hyperthyroidism are poorly understood. We evaluated cortical bone mineral density (BMD) and bone metabolic markers in two boys and five girls, aged 5.7~16 yrs (12.2 ± 3.7 yrs) with hyperthyroidism before and during treatment. BMD (ΣGS/D) was assessed ...

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ژورنال

عنوان ژورنال: Acta Biochimica Polonica

سال: 2017

ISSN: 0001-527X,1734-154X

DOI: 10.18388/abp.2016_1303